@article{Pfleger2025,
title = {Location-specific pathology analysis of monopodial airways in a rabbit model of bronchopulmonary dysplasia: a proof of principle study},
volume = {25},
issn = {1471-2342},
url = {https://doi.org/10.1186/s12880-025-01657-6},
doi = {10.1186/s12880-025-01657-6},
abstract = {The airways of the mammalian lung form a tree-like structure, starting from the trachea and branching out to the terminal bronchioles. This tree is composed of heterogeneous sub-structures or compartments, varying in morphological characteristics such as composition of airway epithelium, presence of cartilage plates, and number of smooth muscle cell layers or lumen diameter. These compartments may vary in their reaction to different pathological stimuli. Thus, when studying a particular lung disease, the compartments need to be investigated individually and not as part of a more global portmanteau compartment. In the symmetrically branching primate lungs, dividing the airway tree into generations is a common method to create morphologically homogeneous groups of airway segments. In common lab animals however, an asymmetrical branching pattern is present, where conventional branching-based grouping methods are unable to create meaningful results.},
number = {1},
journal = {BMC Medical Imaging},
author = {Pfleger, Yannis and Bode, Lena S. C. and Haberthür, David and Hlushchuk, Ruslan and Regin, Yannick and Gie, Andre G. and Salaets, Thomas and Toelen, Jaan and Mühlfeld, Christian and Labode, Jonas},
month = apr,
year = {2025},
pages = {121},
}